Lymphocyte Development

DiGeorge Syndrome

________: had underdeveloped /missing thymus as well as immune deficiency.

Clonal deletion

________: if B cells exhaust all possibilities for L- chain recombination, they are signaled to die by apoptosis in bone marrow.

FDCs

________ provide signal for B cells to finish maturation.

Peripheral tolerance

________: render self- reactive T cells anergic.

Α chain

________ have a lot of V + J segments so they can rearrange many times for productive AND useful rearrangement.

IgM associates

________ w. Igα and Igβ to form B cell receptor complex 2nd checkpoint.